Pharmacology | ANS | 3 – Synaptic Transmission

 

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Synaptic Transmission

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This is lesson no# 3 in Pharmacology and no# 3 in Autonomic Nervous System

In 1 minute you’ll learn synaptic transmission

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In this video we will discuss the synaptic transmission.

The nerve impulses or action potential move through the nerve, as waves of depolarization till reaching the nerve terminal.
This neuron is called presynaptic neuron.

Then influx of Calcium ions occurs at the nerve terminal, allowing vesicles containing neurotransmitters to adhere to the synaptic membrane
and release neurotransmitters by exocytosis.

We should notice that there is no direct contact between the nerve terminal and the effector organ. So, connection between them is done by chemical neurotransmitters.

The neurotransmitter binds to its specific receptor on the effector organ.

This leads to changes in the permeability of cell membrane of the effector organs, that leads to initiation of a response in the effector organ.

Then comes the last step, which is the termination of the neurotransmitter response.
That can be done by 2 mechanisms:

The first one is Enzymatic destruction of the neurotransmitter at synapse.

And the second mechanism is the reuptake of transmitter by specific transporters at nerve terminal  to be stored and re-used.

That’s all for this lecture.
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